![]() ![]() When the student that did that work, Dan Huh, later joined Ingber’s lab as a postdoctoral fellow, Ingber challenged the two of them to bring the idea to life. ![]() Donald Ingber Product Journeyĭonald Ingber, M.D., Ph.D., the Wyss Institute’s Founding Director, was inspired to create Organ Chips in 2007 after watching a demonstration of a “lung-on-a-chip” that contained channels the size of human lung airways but no living cells. We took a game-changing advance in microengineering made in our academic lab, and in just a handful of years, turned it into a technology that is now poised to have a major impact on society. These living, three-dimensional cross-sections of human organs provide a window into their inner workings and the effects that drugs can have on them, without involving humans or animals. These microdevices are composed of a clear flexible polymer about the size of a USB memory stick that contains hollow microfluidic channels lined with living human organ cells and human blood vessel cells. Credit: Wyss Institute at Harvard University Our SolutionĪ multidisciplinary team of Wyss Institute researchers and collaborators have adapted computer microchip manufacturing methods to create “Organs-on-Chips” (Organ Chips): microfluidic culture devices that recapitulate the complex structures and functions of living human organs. Play This short video explains how the design of the chips allows them to emulate organ–level functions. ![]()
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